Base de dados : HANSEN Pesquisa : HANSENIASE VIRCHOWIANA [Descritor de assunto] Referências encontradas : 266 [refinar] Mostrando: 1 .. 20   no formato [Detalhado]

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Id: 27315 Autor: Ganapati, R; Pai, V. V; Shroff, H. J; Gandewar, Kailas. Título: Rate of decline in bacterial index in leprosy; observations after three different chemotherapeutic interventions. Fonte: Int. J. Lepr;65(2):264-266, Jun. 1997. tab, graf. Descritores: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/microbiol Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/microbiol Rifampina/uso terap Ofloxacino/uso terap Localização: BR191.1

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Id: 27300 Autor: Soebono, Haryanto; Giphart, Marius J; Schreuder, Geziena M. T; Klatser, Paul R; Vries, Rene R. P. de. Título: Associations between HLA-DRB1 alleles and leprosy in an Indonesian population. Fonte: Int. J. Lepr;65(2):190-196, Jun. 1997. tab. Resumo: To investigate whether the susceptibility to leprosy (type), subclinical infection with Mycobacterium leprae and the antibody response against M. leprae-specific antigens are associated with HLA-DR phenotypes sequence-specific oligonucleotide HLA-DRB1 and DQA1 typing and antibody assays have been performed in 79 leprosy patients (41 TT/BT and 38 LL/BL) and 50 healthy controls from a Javanese population in Yogyakarta, Indonesia. DRB1*02 was associated with LL/BL [odds ratio (OR) 2.54, 95% confidence interval (CI) 0.97-9.78, p = 0.037 and attributable risk (AR) 41.5%] but not with TT/BT leprosy (p > 0.05). HLA-DRB1*12 was negatively associated with leprosy (either LL/BL or TT/BT [OR 0.33-0.35, p < 0.05, prevented fraction (PF) 58.8%-65.3%]. No significant association was found between HLA-DRB1 or DQA1 type, anti-M. leprae antibody level and subclinical infection with M. leprae. These data indicate that in this population susceptibility to lepromatous leprosy is associated with HLA-DRB1*02, while resistance to leprosy is associated with HLA-DRB1*12. These associations are not paralleled with associations of the same HLA types with anti-M. leprae antibody level. Finally, the results of this study also support the notion that infection with M. leprae per se is not associated with HLA-DRB1 or DQA1 alleles. (AU)^ien. Descritores: Hanseníase Dimorfa/genet Hanseníase Virchowiana/genet Hanseníase Tuberculóide/genet Antígenos HLA-DQ/genet Antígenos HLA-DR/genet Localização: BR191.1

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Id: 27299 Autor: Klatser, Paul R; Janson, Anneke M; Thole, Jelle E. R; Buhrer, Samira; Bos, Corinne; Soebono, Hardyanto; Vries, Rene R. P. de. Título: Humoral and cellular immune reactivity to recombinant M. leprae antigens in HLA-Typed leprosy patients and healthy controls. Fonte: Int. J. Lepr;65(2):178-189, Jun. 1997. tab, graf. Resumo: In our search for Mycobacterium leprae antigens that might specifically induce immunity or immunopathology, we have tested both humoral and cellular immune reactivity against purified recombinant M. leprae antigens in 29 paucibacillary (PB), 26 multibacillary (MB) leprosy patients, and 47 matched healthy contacts. The following M. leprae antigens were tested: 2L-1 (65L-1, GroEl-1), 2L-2 (65L-2, GroEl-2), 4L (SoDA), 43L, 10L (B) and 25L (Sra). The individuals were also typed for HLAD-RB1 and DQB1 in order to see whether leprosy status and/or immune reactivity to these antigens might be associated with certain HLA types. We also tested sera from another 48 patients before, during and after multidrug therapy (MDT) to study the relationship between antibody reactivity to recombinant M. leprae antigens and MDT. Antibody titers to the four recombinant M. leprae antigens tested and to D-BSA were higher in MB patients compared to PB patients and healthy controls, and declined with treatment. From a diagnostic or monitoring point of view none of the recombinant antigens seemed to be an improvement over D-BSA, mainly due to the lower sensitivity. IgG subclasses were measured in positive sera of untreated patients. These were mainly of the IgG1 and IgG3 subclasses, but subclass diversity was also observed and antigen dependent: all four subclasses could be detected against 10L (B), only IgG1 and IgG3 against 43L and only IgG1 against 25L and 2L-1. Cellular immune reactivity against the purified recombinant M. leprae antigens was measured in a lymphocyte stimulation test (LST). As for M. leprae, there was an inverse correlation between antibody and T-cell reactivity. However, the number of LST responders to recombinant antigens was much lower than to M. leprae. The 43L antigen was recognized most often (19%-24% of individuals tested) and more often than the 10L (B) antigen (10%-12%). No clear correlation was observed with leprosy type or protection and, in general, M. leprae nonresponders were also negative with recombinant antigens. Finally, we confirmed that HLA-DRB1*02 is associated with leprosy in this population, and we observed an association between DQB1*0601 and lepromatous leprosy. The number of positive individuals was too small to allow a meaningful analysis of the relationship between HLA type and immune reactivity. Although these data do not allow a conclusion as to one of these purified recombinant antigens being either protection or disease related, the antigen-dependent IgG subclass diversity warrants further study on antigen-specific qualitative differences in immune reactivity that may be relevant for the outcome of an infection with M. leprae. (AU)^ien. Descritores: Hanseníase Dimorfa/sangue Hanseníase Dimorfa/imunol Hanseníase Virchowiana/sangue Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/sangue Hanseníase Tuberculóide/imunol Localização: BR191.1

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Id: 27298 Autor: Richard, Bruce M; Corry, Peter R. Título: Cervical branch of the facial nerve in leprosy. Fonte: Int. J. Lepr;65(2):170-177, Jun. 1997. tab. Resumo: This study demonstrates that the platysma is occasionally palsied in leprosy and that this only occurs when the facial nerve already has some other palsy. That there needs to be a facial palsy before there can be a platysma palsy is strongly suggested, in that there was no case of an isolated platysma palsy. Patients, regardless of age or other factors, could mimic a platysma contraction. This obviates the need for electrical testing to examine for a platysma palsy. It also means that a nonfunctioning platysma on clinical examination is, in fact, a palsied platysma. While lagophthalmos is regularly examined for, and any obvious facial paresis would be noticed, less severe forms of facial muscle paresis will only be found if formally examined for. The mechanism whereby the facial nerve is involved in leprosy is not clarified, but our findings suggest that proximal spread of a lesion that began in the zygomatico-temporal branches and reaches to the facial nerve trunk is more likely than new lesions developing de novo in other peripheral facial nerve branches. That the primary lesion is within the facial nerve trunk in all cases but we only see the frequent zygomatic sequelae due to secondary factors is not excluded. (AU)^ien. Descritores: Hanseníase Dimorfa/diag Hanseníase Virchowiana/diag Hanseníase Tuberculóide/diag Hanseníase/diag Paralisia Facial/diag Limites: Humanos Masculino Feminino Localização: BR191.1

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Id: 27297 Autor: Celik, Onur; Yalcin, Sinasi; Gok, Uzeyir; Yavrucuoglu, Emel; Ozturk, Ahmet; Akyol, Ali. Título: Auditory brain stem evoked potentials in patients with leprosy. Fonte: Int. J. Lepr;65(2):166-169, Jun. 1997. tab. Resumo: Nineteen, randomly selected male patients with lepromatous leprosy were evaluated electrophysiologically. All of these patients had long-standing disease and were treated with dapsone alone. There were statistically significant differences between the values obtained in this group of leprosy patients compared to 20 age-matched controls in auditory brain stem evoked potentials (ABEP). The findings are consistent with a pathologic process located mainly between the cochlear nucleus and the lateral lemniscus in the auditory brain stem pathways. It should be emphasized that our patients had long-standing disease which was treated with dapsone. ABEP could very well be different in leprosy patients diagnosed early and treated for relatively short periods with multidrug therapy. Brain stem evoked response audiometry may be useful for evaluating the possibility of brain stem involvement in leprosy. (AU)^ien. Descritores: Hanseníase Virchowiana/diag Hanseníase Virchowiana/quimioter Hansenostáticos/uso terap Localização: BR191.1

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Id: 27296 Autor: Kochar, Dhanpat Kumar; Gupta, Dharam Veer; Sandeep, Chauhan; Halwai, Mahendra; Kumawat, Banshi Lal. Título: Study of brain stem auditory-evoked potentials (BAEPs)and visual-evoked potentials (VEPs) in leprosy. Fonte: Int. J. Lepr;65(2):157-165, Jun. 1997. tab. Resumo: A study of brain stem auditory-evoked potentials (BAEPs) and visual-evoked potentials (VEPs) was done on 25 newly diagnosed patients with leprosy whose diagnosis was confirmed by skin biopsy. The results were compared with 25 age- and sex-matched healthy controls. In BAEPs the important observations were the prolonged latency of wave V in 13 (52%), delayed interpeak latency (IPL) of wave I-III in 5 (20%) cases, of wave III-V in 12/25 (40%), suggesting a conduction abnormality of the VIII cranial nerve in its peripheral part, in its nucleus and in its connection in the brain stem. In VEPs, a delayed peak latency of major positive potential (P100) was seen in 20 cases (80%; 11/13, 84.6% TT; 7/10, 70% LL; 2/2, 100% BL), suggestive of subclinical optic nerve involvement. The BAEPs and VEPs were both abnormal in 10 cases (40%; 3/13, 23% TT; 5/10, 50% LL; 2/2, 100% BL). Conduction abnormalities of the central nervous system (CNS) were observed more frequently in lepromatous leprosy, as in other forms of peripheral neuropathy such as hereditary motor sensory neuropathy type I (HMSN I). There is a fair possibility of similar multiple demyelinating lesions in the CNS also, as is seen in leprous peripheral neuropathy. This hypothesis requires further strengthening by an extensive study of multimodality evoked potentials with magnetic resonance imaging in the patients. Histopathological and immunofluorescent studies of autopsy material of the brain can also contribute significantly to solve the dilemma. (AU)^ien. Descritores: Hanseníase Dimorfa/fisiopatol Hanseníase Virchowiana/fisiopatol Hanseníase Tuberculóide/fisiopatol Limites: Humanos Masculino Feminino Localização: BR191.1

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Id: 27282 Autor: Alfaro-Bustamante, Fernando; Ramirez-Flores, Gabriela; Gonzales-Mendonza, Amado; Islas-Rodriguez, Alfonso; Fafutis-Morris, Mary. Título: Effect of phorbol myristate acetate (PMA) and ionophore A23187 on interleukin-2 levels and proliferation of activated T lymphocytes from patients with lepromatous leprosy. Fonte: Int. J. Lepr;65(1):73-79, Mar., 1997. tab, graf. Resumo: The immunodeficiency present in patients with lepromatous leprosy is characterized by the limited proliferation of T lymphocytes, and is explained in part by the impaired synthesis of interleukin-2 (IL-2). Diacylglycerol (DAG) and calcium produce the activation of PKC, ERK and JNK kinases, implying a normal IL-2 response. Phorbol esters, such as PMA, can substitute for DAG and are mitogenic to human T and B cells activating several cytokine-encoding genes. Ionophore A23187 increases calcium permeability across the cellular membrane to the cytosol of lymphoid cells and is considered a co-mitogen of T lymphocytes. Here we report that: 1) PHA-activated T lymphocytes from LL patients can be separated in vitro into two groups: a) responders (R) with a stimulation index (SI) of > 10 and (b) nonresponders (NR) with a SI of < 10. 2) The proliferative responses of cells from LL(R), LL(NR) and normal subjects were measured after being stimulated with: I, PHA, PMA, PMA + I PHA + PMA and PHA + PMA + ionophore (PPI). The most important result occurs in LL(NR) patients whose cells did not respond to PHA stimulation but increased to normal levels of proliferation when they were stimulated with PMA. Furthermore, the three groups, (NR, R and normals) strongly increased their responses when they were incubated with PPi. 3) Finally, Il-2 concentrations in the supernatants of cultures of T lymphocytes from LL(NR), LL(R) and controls were relatively low when they were incubated with PHA or PMA, but the addition of ionophore to PMA and the combination of PHA + PMA strongly increased the production of IL-2 in all of them, reaching the optimum IL-2 concentration when PPI is used. It can be concluded that the use of PMA, analogous to DAG, and ionophore A23187 (calcium increaser) in cultures of mitogen-activated T lymphocytes from LL patients induced the expression of the IL-2 gene, thus correcting the inadequate proliferation of T cells from LL patients. (AU)^ien. Descritores: Hanseníase Virchowiana/imunol Acetato de Tetradecanoilforbol/farmacol Localização: BR191.1

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Id: 27279 Autor: Barrera, Silvia de la; Finiasz, Marta; Fink, Susana; Valdez, Raul; Bottasso, Oscar; Balina, Luis Maria; Sasiain, Maria del Carmen. Título: Differential development of CD4 and CD8 cytotoxic T cells (CTL) in PBMC across the leprosy spectrum IL-6 with IFN-gamma or IL-2 generate CTL in multibacillary patients. Fonte: Int. J. Lepr;65(1):45-55, Mar., 1997. tab, graf. Resumo: In the present study we evaluated the contribution of CD4 and CD8 T cells on the antigen-specific cytotoxic activity induced by whole Mycobacterium leprae in leprosy patients and normal controls (N) as well as the modulation of this activity by some cytokines. Peripheral blood mononuclear cells (PBMC) from N or from leprosy patients were stimulated with antigen in the presence or absence of cytokines for 7 days. M. leprae-stimulated PBMC were depleted of CD4 or CD8 antigen-bearing cells and employed as effector cells in a 4-hr [31Cr]-release assay against autologous M. leprae-pulsed macrophages. Our results demonstrate that both CD4 and CD8 T cells contribute to M. leprae-induced cytotoxic activity, with differences observed in paucibacillary (PB) and multibacillary (MB) patients. CD8-mediated cytotoxic activity is higher than that of CD4 cells in PB patients, while in MB patients CD4 cytotoxicity is predominant. Our data also demonstrate that the generation of CD4 and CD8 cytotoxic T lymphocytes (CTL) can be modulated differentially by interleukin-4 (IL-4), IL-6, gamma interferon (IFN-gamma), or IL-2. Although MB patients developed the lowest CTL response, cytokines such as IL-6 plus IL-2 or IFN-gamma were able to generate both CD4 and CD8 cytotoxic T cells from MB patients. In PB patients, IL-6 plus IFN-gamma displayed the highest stimulation on CD8 effector cells. Thus, an important role may be assigned to IL-6, together with IL-2 or IFN-gamma, in the differentiation of M. leprae-specific CTL effector cells. (AU)^ien. Descritores: Linfócitos T CD4-Positivos/imunol Linfócitos T CD8-Positivos/imunol Hanseníase Dimorfa/imunol Hanseníase Virchowiana/imunol Hanseníase Tuberculóide/imunol Localização: BR191.1

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Id: 27278 Autor: Carsalade, Georges-Yves de; Wallach, Daniel; Spindler, Edith; Pennec, Jean; Cottenot, Francois; Flageul, Beatrice. Título: Daily multidrug therapy for leprosy; results of a fourteen-year experience. Fonte: Int. J. Lepr;65(1):37-44, Mar., 1997. graf. Resumo: Between 1980 and 1994, 67 new or relapsing leprosy patients were treated by daily administered multidrug regimens. Tuberculoid patients (23 TT/BT) received either bitherapy [rifampin + dapsone or clofazimine (RMP + DDS or CLO)] or tritherapy [RMP + DDS and/or CLO and/or ethionamide (ETH)] until clinical cure. Lepromatous patients (44 BB/BL/LL) received tritherapy (RMP + DDS and/or CLO and/or ETH) at least until bacteriological negativity. Of the 23 tuberculoid patients only one patient (5%) was cured at 6 months and about 70% needed between 6 and 24 months of treatment to obtain clinical cure (mean 19.5 months). In the 44 lepromatous patients, the achievement of bacteriological negativity was significantly linked to the initial bacterial index (BI), and it occurred after 2 to 7 years (mean 66.5 months) of multidrug therapy (MDT). The average BI decrease per year was 1.1+ during the first year, 0.9+ the second year, and then < 0.5+ per year. Reactional states significantly (p < 0.01) influenced the BI course: reversal reactions (RR) accelerated while erythema nodosum leprosum (ENL) delayed the BI decrease. Three of the 23 (13%) tuberculoid and 19 of the 44 (43%) lepromatous patients (p < 0.02) exhibited a RR and 18 of 44 (41%) lepromatous patients had ENL during MDT. A late RR (LRR) was observed in 1 (5%) and 6 (17%) of our tuberculoid and lepromatous patients, respectively, and 3 (8%) of our lepromatous patients suffered post-MDT ENL. No confirmed relapse has been observed within a follow-up period of 6 months to 7 years and 3 months [59 person-years at risk (PYR)] for TT/BT patients and of 4 months to 5 years and 10 months (100 PYR) for BB/BL/LL patients. When compared to the recommended WHO/MDT, it appears that daily MDT does not increase the clinical or the bacteriological cure rates either at 6 months in paucibacillary tuberculoid patients or at 2d years in multibacillary lepromatous patients. Moreover, as does the WHO/MDT, our regimens show a high frequency of reactional states both during and after treatment. This fact constitutes the main new problem of the actual treatment of leprosy. (AU)^ien. Descritores: Hanseníase Dimorfa/quimioter Hanseníase Virchowiana/quimioter Hanseníase Tuberculóide/quimioter Limites: Humanos Masculino Feminino Localização: BR191.1

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Id: 27274 Autor: Memon, Riaz Z; Kifayet, Arnawaz; Shahid, Firdaus; Lateef, Anisa; Chiang, Thomas J; Hussain, Rabia. Título: Low serum HDL-cholesterol is associated with raised tumor necrosis factor-alpha during ENL reactions. Fonte: Int. J. Lepr;65(1):1-11, Mar., 1997. tab, graf. Resumo: The concentrations of serum lipids and tumor necrosis factor (TNF) were measured in leprosy patients across the spectrum of the disease and in erythema nodosum leprosum (ENL) patients at the onset of the reaction and after the reaction had clinically subsided. Lepromatous/borderline lepromatous (LL/BL) patients had significantly higher serum triglyceride and lower HDL-cholesterol levels; there was no such change in the tuberculoid/borderline tuberculoid (TT/BT) patients. The household contacts (HC) of the LL/BL patients also had significantly lower serum HDL levels. ENL patients during the acute phase of the reaction had significantly lower total, LDL-, HDL-cholesterol levels compared to the stable LL/BL patients, and these changes were reversible to pre-ENL levels after the reaction had subsided. Serum TNF levels were significantly higher in household contacts and in LL/BL patients but were not statistically different in TT/BT patients. Serum TNF levels were also significantly higher during the acute phase of ENL, and declined after the clinical remission of the reaction to levels comparable with those of LL/BL patients. There was a significant negative correlation between serum TNF and HDL-cholesterol levels during and after ENL reaction. However, there was no such correlation between TNF and total or LDL-cholesterol levels in ENL patients. Our results suggest that the changes in HDL-cholesterol metabolism are a specific part of the host response to lepromatous leprosy and to the ENL reaction and may be mediated by increased TNF production. (AU)^ien. Descritores: Hanseníase Virchowiana/sangue Hanseníase Tuberculóide/sangue Colesterol HDL/anal Colesterol HDL/sangue Colesterol HDL/metab Colesterol LDL/anal Colesterol LDL/sangue Colesterol LDL/metab Limites: Humanos Masculino Feminino Adolescente Adulto Meia-Idade Localização: BR191.1

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Id: 27240 Autor: Ebenezer, Gigi J; Gnanaraj, Lionel; Ebenezer, Mannan; Job, Charles K. Título: Lepromatous orchitis associated with seminoma. Fonte: Int. J. Lepr;66(3):385-386, Sept. 1998. ilus. Descritores: Seminoma/etiol Seminoma/patol Hanseníase Dimorfa/compl Hanseníase Virchowiana/compl Orquite/compl Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3clinot.pdf - en. Localização: BR191.1

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Id: 27233 Autor: Rea, Thomas H; Sieling, Peter A. Título: Delayed-type hypersensitivity reactions followed by erythema noodosum leprosum. Fonte: Int. J. Lepr;66(3):316-327, Sept. 1998. tab. Resumo: Reported herein are 13 borderline lepromatous (BL) or subpolar lepromatous (LLs) patients who presented with or developed delayed-type hypersensitivity (DTH) reactions after initiation of antibacterial therapy, but who subsequently developed erythema nodosum leprosum (ENL), the DTH to ENL group. During the same time, three LLs patients had ENL followed by relapse-associated DTH, a significant (p < 0.05) difference in sequence of the two conditions. The DTH to ENL group had statistically significant higher biopsy indexes at the time of diagnosis of the DTH reaction compared with two DTH control groups, 7 multibacillary patients presenting with DTH reactions and 15 BL or LLs who developed DTH reactions after starting treatment but had no ENL. DTH-associated histologic changes were less well developed in the DTH to ENL group than in either of the two control groups. In the DTH to ENL group, 77% required prednisone in addition to thalidomide to achieve a complete remission in contrast to only 10% of 21 ENL clinical controls. In the DTH to ENL group, the classical histologic ENL pattern was present in only 31% of these patients, in contrast to 88% of 33 ENL histologic controls. In 9 of 9 of the DTH to ENL patients studied, after the ENL remitted, Mycobacterium leprae-sonicate-stimulated lymphocyte transformation tests gave stimulation indexes within the range of our tuberculoid (TT) and borderline tuberculoid (BT) patients, in contrast to absent responses in 6 ordinary, longterm-treated patients who had had ENL. (AU)^ien. Descritores: Hanseníase Dimorfa/quimioter Hanseníase Dimorfa/imunol Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n3/v66n3a02.pdf - en. Localização: BR191.1

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Id: 27170 Autor: Rivero-Nava, Laura; Quesada-Pascual, Fausto; Estrada-Garcia, Iris; Estrada-Parra, Sergio; Santos-Argumedo, Leopoldo. Título: Cellular immune responses of health and Mycobacterium leprae-inoculated armadillos (Dasypus novemcinctus). Fonte: Int. J. Lepr;66(4):485-487, Dec. 1998. graf. Descritores: Tatus/genet Hanseníase Virchowiana/imunol Mycobacterium leprae/imunol Limites: Animais Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4cor02.pdf - en. Localização: BR191.1

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Id: 27168 Autor: Freire, Beatriz F. A; Ferraz, Alexandre A. F; Nakayama, Edson; Ura, Somei; Queluz, Thais T. Título: Anti-neutrophil cytoplasmic antibodies (ANCA) in the clinical forms of leprosy. Fonte: Int. J. Lepr;66(4):475-482, Dec. 1998. tab. Resumo: Anti-neutrophil cytoplasmic antibodies (ANCA) are autoantibodies against enzymes present in primary granules of neutrophils and lysosomes of monocytes detected in systemic vasculitis and in other diseases, including infections. ANCA are markers of active Wegener granulomatosis, which presents some anatomo-pathologic and immune response features similar to those of leprosy. Thus, we raised the hypothesis that ANCA may be present in leprosy as markers specifically linked to the presence of vasculitis. The aim of this study was to determine the presence of ANCA in leprosy and its correlation with the clinical forms of the disease. Sera from 60 normal individuals and from 59 patients with different clinical forms of leprosy were studied. The patients were also allocated into reactional and nonreactional groups. By indirect immunofluorescence, ANCA were positive, an atypical pattern (A-ANCA), in 28.8% of the patient sera. A-ANCA predominated, although not significantly (p > 0.05), in the reactional groups 37.9% vs 20.0%), and in those at the lepromatous pole (41.6% vs 20.0%). There was no correlation between ANCA positivity and either disease duration, disease activity, or therapeutic regimen (p > 0.05). An interesting finding was the correlation between ANCA and gender: 94.1% of ANCA-positive patients were males (p < 0.01), a feature that so far has not been reported in ANCA-related diseases and for which there is no explanation at the moment. By ELISA, the sera of the lepromatous leprosy patients did not show activity against either PR3, MPO, HLE, the most common ANCA antigens. Because A-ANCA are nonspecific, this finding requires further investigation for the determination of the responsible antigen(s). In conclusion, A-ANCA are present in 28.8% of leprosy patients but are not related to vasculitis in the erythema nodosum leprosum reaction and are not a marker of a specific clinical form. (AU)^ien. Descritores: Hanseníase Virchowiana/diag Hanseníase Virchowiana/imunol Granulócitos/imunol Limites: Humanos Masculino Feminino Criança Adolescente Adulto Idoso Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1998/pdf/v66n4/v66n4a05.pdf - en. Localização: BR191.1

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Id: 27144 Autor: Sinha, Sudhir; Mcentegart, Anne; Girdhar, Bhawneshwar K; Bhatia, Amarjit S; Sengupta, Utpal. Título: Appraisal of two mycobacterium leprae specific serological assays for monitoring chemotherapy in lepromatous (LL/BL) leprosy patients. Fonte: Int J Lep;57(1):24-32, Mar. 1989. ^bgraf, ^btab. Resumo: Two of the Mycobacterium leprae-specific assays--a serum antibody competition (for an epitope on 35-kDa protein) test (SACT) and an enzyme-linked immunosorbent assay (ELISA) for the disaccharide epitope of phenolic glycolipid-I (PGDS)--were comparatively evaluated as tools for monitoring chemotherapy in 125 lepromatous leprosy (LL/BL) patients. An adaptation of the SACT from a radioimmunoassay (RIA) to an ELISA procedure is also described. A moderate but statistically significant correlation was observed between the assays, although SACT appeared to be the more sensitive of the two. Levels of antibodies correlated better with the bacterial index (BI) than with the duration of treatment. However, wide individual variations in antibody levels (for a specific duration of treatment or BI) were seen in treated as well as untreated patients. Anti-PGDS antibody response of the IgG type was poorer than that of the IgM type and, apparently, it did not have a bearing on either treatment duration or the BI. Further studies will be needed to clarify whether the treated patients showing a negative (or low) BI and high antibody levels were harboring hidden foci of active infection, and whether treatment could safely be terminated in patients showing low values for both BI and antibody^ien. Descritores: Hanseníase Virchowiana/quimioter Hanseníase Virchowiana/imunol Mycobacterium leprae/imunol Mycobacterium leprae/isol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a04.pdf - en.

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Id: 27143 Autor: Kolhi, Majula; Vaishnavi, Chetana; Garg, Uttam Chand; Ganguly, Nirmal Kumar; Kaur, Surrinder. Título: Urinary excretion of renal brush-border enzymes in lepromatous leprosy - a preliminary investigation. Fonte: Int J Lep;57(1):20-23, Mar. 1989. ^bgraf. Resumo: Activities of the brush-border enzymes, alkaline phosphatase, maltase, leucine aminopeptidase, and gamma-glutamyl transpeptidase, were measured in urine samples of 25 lepromatous leprosy patients and an equal number of age-matched healthy controls. None of the patients were shown to be suffering from any other systematic disease. The enzymatic activities were shown to be significantly elevated in leprosy patients when compared to controls^ien. Descritores: Hanseníase Virchowiana/compl Hanseníase Virchowiana/enzimol Hanseníase Virchowiana/urina Nefropatias/urina Monoester Fosfórico Hidrolases/urina Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a03.pdf - en. Localização: Br191.1

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Id: 27142 Autor: Job, Charles K; kahkonen, Martti E; Jacobson, Robert R; Hastings, Robert C. Título: Single lesion subpolar lepromatous leprosy and its possible mode of origin. Fonte: Int J Lep;57(1):12-19, Mar. 1989. ^bilus. Resumo: Three case reports of patients with a single, nodular, subpolar lepromatous skin lesion, one on the left elbow, another on the posterior aspect of the left leg, and the third on the extensor ulnar aspect of the right forearm, are presented. The lesions, clinically and histopathologically, resemble lepromas which develop at the site of experimental inoculation of Mycobacterium leprae in armadillos. These are sites on the body which are likely to be traumatized. With the distinct possibility of the presence of viable M. leprae in the soil of Louisiana and Texas from wild armadillos with the natural disease, it is suggested that these three patients acquired the infection from the environment and had inoculation lepromas^ien. Descritores: Hanseníase Virchowiana/etiol Hanseníase Virchowiana/imunol Hanseníase Virchowiana/microbiol Mycobacterium leprae/isol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n1/v57n1a02.pdf - en. Localização: Br191.1

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Id: 27135 Autor: Shu-Guang, Li; Vries, Rene RP. Título: HLA DQ molecules may be products of an immune suppression gene responsible for Mycobacterium leprae specific nonresponsiveness. Fonte: Int J Lepr;57(2):554-555, June 1989. ^bgraf, ^btab. Descritores: Hanseníase Virchowiana/genet Hanseníase Virchowiana/imunol Antígenos HLA-DQ/genet Antígenos HLA-DQ/imunol Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2cor01.pdf - en. Localização: Br191.1

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Id: 27131 Autor: Job, Charles K; Path, FRC. Título: Nerve damage in leprosy. Fonte: Int J Lepr;57(2):532-539, June 1989. . Descritores: Hanseníase Dimorfa/compl Hanseníase Dimorfa/patol Hanseníase Virchowiana/compl Hanseníase Virchowiana/patol Hanseníase Tuberculóide/compl Hanseníase Tuberculóide/patol Hanseníase/compl Hanseníase/patol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2soalec01.pdf - en. Localização: Br191.1

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Id: 27127 Autor: Mukherjee, Ashok; Misra, Radhey S; Meyers, Wayne M. Título: An electron microscopic study of lymphatics in the dermal lesions of human leprosy. Fonte: Int J Lepr;57(2):506-510, June 1989. ^bilus. Resumo: The dermal lymphatic vessels in lepromatous and tuberculoid leprosy lesions were studied by light- and electron-microscopy. In the lepromatous patient, lymphatic vessels were seen in both intra- and peri-granulomatous areas. The lymphatic lining cells contained lipid droplets, lysosomes, and numerous pinocytotic vesicles. Cells bearing bacilli were only occasionally seen. In the tuberculoid cases, lymphatic vessels were seen only along the edges of the granulomas and the lining cells were less prominent. Inflammatory cells, both lymphocytes and histiocytes, were found traversing the walls of lymphatic vessels in both groups of patients. The results of the study confirm the continued and increased functioning of the lymphatic drainage system in dermal leprosy lesions, and indicates that it may be a major route for the clearance of lipids from the lipid-rich bacilliferous lesions in the lepromatous patient. The lymphatic pathway appears to be a minor pathway for the dissemination of Mycobacterium leprae in comparison with the blood vascular system^ien. Descritores: Hanseníase Virchowiana/microbiol Hanseníase Virchowiana/patol Hanseníase Tuberculóide/microbiol Hanseníase Tuberculóide/patol Limites: Humanos Meio Eletrônico: http://hansen.bvs.ilsl.br/textoc/revistas/intjlepr/1989/pdf/v57n2/v57n2a09.pdf - en. Localização: Br191

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